Bernard S. Strauss, PhD Bernard S. Strauss
The Mechanisms of Mutations

Professor Emeritus, Molecular Genetics and Cell Biology, Committee on Cancer Biology, Committee on Genetics, Genomics & Systems Biology

B.S., Chemistry, City College of New York, 1947
Magna cum laude Ph.D., Biochemistry and Immunology, California Institute of Technology, 1950


Research Summary

During the period from 1960 until about 2008 this laboratory was involved in studies on DNA repair and on the mechanism of mutation, particularly attempting to understand the role of polymerases and editing nucleases.

Selected Publications

Strauss B. PubMed, The New York Times, and The Chicago Tribune as Tools for Teaching Genetics. Genetics. 2005 171:1449-1454. (PubMed)

Strauss B. ROSY and JIM: The Mystery of THE DOUBLE HELIX. Perspect Biol Med. 2004 Summer;47(3):443-8. (PubMed)

Strauss BS. The "A" rule revisited: polymerases as determinants of mutational specificity. DNA Repair (Amst). 2002 Feb 28;1(2):125-35. (PubMed)

Sagher D, Karrison T, Schwartz JL, Larson R, Meier P, Strauss B. Low O6-alkylguanine DNA alkyltransferase activity in the peripheral blood lymphocytes of patients with therapy-related acute nonlymphocytic leukemia. Cancer Res. 1988 Jun 1;48(11):3084-9. (PubMed)

Sagher D, Strauss B. Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides. Biochemistry. 1983 Sep 13;22(19):4518-26. (PubMed)

Higgins NP, Kato K, Strauss B. A model for replication repair in mammalian cells. J Mol Biol. 1976 Mar 5;101(3):417-25. (PubMed)

Pauli RM, Strauss BS. Proliferation of human peripheral lymphocytes. Characteristics of cells once stimulated or re-stimulated by concanavalin A. Exp Cell Res. 1973 Dec;82(2):357-66. (PubMed)

Tsuda Y, Strauss BS. A deoxyribonuclease reaction requiring nucleoside di- or triphosphates. Biochemistry. 1964 Nov;3:1678-84. (PubMed)

Okubo S, Stodolsky M, Bott K, Strauss BS. Separation of the transforming and viral deoxyribonucleic acids of a transducing bacteriophage of Bacillus subtilis. Proc Natl Acad Sci U S A. 1963 Oct;50:679-86. (PubMed)

Strauss BS. Differential destruction of the transforming activity of damaged deoxyribonucleic acid by a bacterial enzyme. Proc Natl Acad Sci U S A. 1962 Sep 15;48:1670-5. (PubMed)

Strauss, B.S. An Outline of Chemical Genetics. 1960. W.B. Saunders. Co., Philadelphia. (


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