David Pincus, PhD David Pincus

UC Berkeley, BA Molecular & Cell Biology 12/2004
UCSF, San Francisco, CA, PhD Biochemistry 09/2012
Whitehead Institute, Cambridge, MA, 09/2018


Research Summary

David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS. The Pincus Lab studies "System Mechanics of Cellular Stress Responses", defined as quantitative control processes cells employ to sense and respond to environmental and endogenous perturbations. David is trained in approaches in biochemistry, biophysics, genetics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models, and applies this toolkit to investigate three interconnected areas: 1) Hsf1, chaperones, and proteostasis networks 2) Stress responsive kinase signaling 3) Stress responsive gene expression The goal of the research program is to understand the establishment and maintenance of cell-level homeostasis.

Keywords proteostasis, Hsf1, kinase, chaperone, Hsp70, Hsp40, Hsp90, Phosphorylation

Selected Publications

Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA. Engineering allosteric regulation in protein kinases. Sci Signal. 2018 Nov 06; 11(555). View in: PubMed

Pincus D, Anandhakumar J, Thiru P, Guertin MJ, Erkine AM, Gross DS. Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome. Mol Biol Cell. 2018 Oct 17; mbcE18060353. View in: PubMed

Zheng X, Beyzavi A, Krakowiak J, Patel N, Khalil AS, Pincus D. Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity. Cell Rep. 2018 Mar 20; 22(12):3099-3106. View in: PubMed

Krakowiak J, Zheng X, Patel N, Feder ZA, Anandhakumar J, Valerius K, Gross DS, Khalil AS, Pincus D. Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response. Elife. 2018 02 02; 7. View in: PubMed

Zheng X, Krakowiak J, Patel N, Beyzavi A, Ezike J, Khalil AS, Pincus D. Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation. Elife. 2016 11 10; 5. View in: PubMed


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