Stephen J. Kron, MD, PhD Stephen J. Kron
Cell Cycle Checkpoints

Professor, Molecular Genetics and Cell Biology, Committees on Genetics, Genomics and Systems Biology; Cancer Biology; Clinical Pharmacology and Pharmacogenomics; and Molecular Medicine, and The College

B.A., Biochemistry, University of Pennsylvania, 1982; M.S.E, Bioengineering, University of Pennsylvania, 1983; M.D.-Ph.D., Cell Biology, Stanford University, 1990

 

Research Summary

The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.

 

Attention: Post-doc inquiries welcomed. Please, contact Dr. Kron at

 


Selected Publications

E.V. Efimova, N. Ricco, E. Labay, H.J. Mauceri, A.C. Flor, A. Ramamurthy, H.G. Sutton, R.R. Weichselbaum and S.J. Kron, "HMG-CoA reductase inhibition delays DNA repair and promotes senescence after tumor irradiation,"  2017 Oct 13., pii: molcanther.0288.2017 (PubMed)

O.K. Appelbe, K.D. Moynihan, A. Flor, N. Rymut, D.J. Irvine and S.J. Kron, "Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide," J. Controlled Release, 266:248-255, 2017 (PubMed)

A. Flor, D. Wolfgeher, D. Wu and S.J. Kron, "A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence," Cell Death Discovery, 3:17075, 2017 (PubMed)

H. Bar Yosef, N.V. Gonzalez, S. Ben Aroya, S.J. Kron and D. Kornitzer, "Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis," Scientific Reports, 7:5692, 2017 (PubMed)

O.K. Appelbe, Q. Zhang, C.A. Pelizzari, R.R. Weichselbaum and S.J. Kron, "Image-guided radiotherapy targets macromolecules through altering the tumor microenvironment," Molecular Pharmaceutics, 3:3457-3467, 2016 (PubMed)

A. Flor, A. Doshi and S.J. Kron, "Modulation of therapy-induced senescence by reactive lipid aldehydes," Cell Death Discovery, 2:16045, 2016 (PubMed)

E. Labay, H.J. Mauceri, E.V. Efimova, A.C. Flor, H.G. Sutton, S.J. Kron and R.R. Weichselbaum, "Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers," Oncotarget, 7:33919-33, 2016 (PubMed)

E.V. Efimova, S. Takahashi, N.A. Shamsi, D. Wu, E. Labay, O.A. Ulanovskaya, R.R. Weichselbaum, S.A. Kozmin and S.J. Kron, "Linking cancer metabolism to DNA repair and accelerated senescence," Molecular Cancer Research, 14:173-84, 2016 (PubMed)

J. Lee, A. Manning, D. Wolfgeher, J. Jelenska, K.A. Cavanaugh, H. Xu, S.M. Fernandez, R.W. Michelmore, S.J. Kron and J.T. Greenberg, "Acetylation of a NB-LRR plant immune-effector complex suppresses immunity," Cell Reports, 13:1670-82, 2015 (PubMed)

A. Shamirian, O. Applebe, Q. Zhang, B. Ganesh, S.J. Kron and P. Snee, "A toolkit for bioimaging using near-infrared AgInS2/ZnS quantum dots," J. Materials Chemistry B, 3:8188-8196, 2015 (rsc.org)

A.W. Truman, K. Kristjansdottir, D. Wolfgeher, N. Ricco, A. Mayampurath, S.L. Volchenboum, J. Clotet, and S.J. Kron, "Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveals chaperone-dependent regulation of ribonucleotide reductase," Proteomics, 112:285-300, 2015 (PubMed)

A.C. Flor, J.H. Williams, K.M. Blaine, R.C. Duggan, A.I. Sperling, D.A. Schwartz and S.J. Kron, "DNA-Directed Assembly of Antibody-Fluorophore Conjugates for Quantitative Multiparametric Flow Cytometry," Chembiochem. Jan 24;15(2):267-75, 2014 (PubMed)

F.O. Balogun, A.W. Truman and S.J. Kron. "DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast", DNA Repair 12:751-60, 2013 (PubMed)

 

 

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