The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.
inquiries welcomed. Please, contact Dr. Kron at
Appelbe OK, Zhang Q, Pelizzari CA, Weichselbaum RR, Kron SJ. Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment.
Mol Pharm. 2016 Sep 1. [Epub ahead of print] s(PubMed)
Flor AC, Doshi AP, Kron SJ. Modulation of therapy-induced senescence by reactive lipid aldehydes. Cell Death Discov. 2016;2. Epub 2016 Jul 4. (PubMed)
Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR. Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers. Oncotarget. 2016 Apr 25. [Epub ahead of print] (PubMed)
E.V. Efimova, S. Takahashi, N.A. Shamsi, D. Wu, E. Labay, O.A. Ulanovskaya, R.R. Weichselbaum, S.A. Kozmin and S.J. Kron, "Linking cancer metabolism to DNA repair and accelerated senescence," Molecular Cancer Research, online, 2015 (PubMed)
J. Lee, A. Manning, D. Wolfgeher, J. Jelenska, K.A. Cavanaugh, H. Xu, S.M. Fernandez, R.W. Michelmore, S.J. Kron and J.T. Greenberg, "Acetylation of a NB-LRR plant immune-effector complex suppresses immunity," Cell Reports, 13:1670-82, 2015 (PubMed)
A. Shamirian, O. Applebe, Q. Zhang, B. Ganesh, S.J. Kron and P. Snee, "A toolkit for bioimaging using near-infrared AgInS2/ZnS quantum dots," J. Materials Chemistry B, 3:8188-8196, 2015 (rsc.org)
A.W. Truman, K. Kristjansdottir, D. Wolfgeher, N. Ricco, A. Mayampurath, S.L. Volchenboum, J. Clotet, and S.J. Kron, "Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveals chaperone-dependent regulation of ribonucleotide reductase," Proteomics, 112:285-300, 2015 (PubMed)
A.C. Flor, J.H. Williams, K.M. Blaine, R.C. Duggan, A.I. Sperling, D.A. Schwartz and S.J. Kron, "DNA-Directed Assembly of Antibody-Fluorophore Conjugates for Quantitative Multiparametric Flow Cytometry," Chembiochem. Jan 24;15(2):267-75, 2014 (PubMed)
F.O. Balogun, A.W. Truman and S.J. Kron. "DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast", DNA Repair 12:751-60, 2013 (PubMed)
A.W. Truman, K. Kristjansdottir, D. Wolfgeher, N. Hasin, S. Polier, H. Zang, S. Perrett, C. Prodromou, G.W. Jones and S.J. Kron, "CDK-dependent Hsp70 phosphorylation controls G1 cyclin abundance and cell cycle progression," Cell, 151:1308-18, 2012 (PubMed)
G. Zhou, F. Khan, Q. Dai, J.E. Sylvester, and S.J. Kron, "Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS," Molecular Biosystems, 8:2395-404, 2012 (PubMed)
J.E. Sylvester, T.S. Bray and S.J. Kron, "Annotator: Post-processing software for generating function-based signatures from quantitative mass spectrometry," J. Proteome Res. 11:1521-36, 2012 (PubMed)
Y. Meng, E.V. Efimova, K.W. Hamzeh, T.E. Darga, H.J. Mauceri, Y.-X. Fu, S.J. Kron and R.R. Weichselbaum, "Radiation-inducible immunotherapy for cancer: Senescent tumor cells as a cancer vaccine," Mol Ther. 20:1046-55, 2012 (PubMed)